Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft: MAK Commission; 1 Accuracy was evaluated by the examiner of the method by usage of internal standards d 4 ‐2,6‐TDA, d … The systemic nature of TDI carcinogenicity was demonstrated by the appearance of tumors at multiple sites (pancreas, liver, skin, mammary glands, and circulatory system). Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). 0000004304 00000 n 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. Hazardou s in case of skin contact (permeator). 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. 2. (February 1996). Key health and ecological effects (hazard) Risk assessment outcomes. 0000001270 00000 n 8. Identification . Methylene Bisphenyl Isocyanate. Baltimore, MD: The Williams and Wilkins Co., p. 141. 1. 0000008879 00000 n Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. Flash point. Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. Beilstein/REAXYS Number 744602 . 0000000016 00000 n - ; A NIOSH In ... Styrene, toluene, toluene-2, 4-diisocyanate, vinyl pyridine, formaldehyde, butadiene, methyl chloroform, and resorcinol. Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. startxref Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. Toluene-2,4-Diisocyanate. Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Boiling points. Reaction with water to form Carbon Dioxide [Merck 11th ed. Summary . Section 5 - Apprisal of Employeesof Hazards from 10 Toluene Diisocyanate Section 6 - Work Practices and Control Procedures 10 Section 7 - Sanitation Practices 11 Section 8 - Monitoring and Recordkeeping 12 Requirements II. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. <> : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent %PDF-1.5 %���� 26 33 Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed SP - Indicates … Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanate are two training programs designed to inform employers and employees of the potential hazards associated with the handling of methylene diphenyl diisocyanates (MDI) and toluene diisocyanates (TDI) and best practices to minimize potential risks. Potential explosion if stored in polyethylene containers due to … This is based on test results presently Slightly hazardous in case of skin contact (corrosive). Melting point. 17034 Classification. Catalog Number Cat. Methyl Isocyanate. Toluene Hazards & Safety Tips. endstream endobj 27 0 obj<. Compendium of Chemical Hazards: Toluene diisocyanate Page 3 of 4 General Information Ingestion of toluene diisocyanate may cause nausea, vomiting and abdominal pain. Isophorone Diisocyanate. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. 0000009752 00000 n Each notification may be associated with multiple companies. The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). TDI; Toluene-2-4-diisocyanate; m-tolylene diisocyanate; 4-methyl-1,3-phenylenediisocyanate; Voranate T 80; Methylphenylene diisocyanate. 0000001407 00000 n Mutat Res 79:363-375. Similarly, spray mists can impose a significant health hazard. ���Y? 26 0 obj<> endobj (January 1986). ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation 0000003317 00000 n $25.00. health hazards acute and chronic: target organs: eyes, skin, respiratory tract. Product form : Substance Substance name : Toluene CAS-No. Gunter BJ [1975]. US Environmental Protection Agency, Office of Air Quality Planning and Standards (1994), TOLUENE 2,4-DIISOCYANATE (accessed, March, 1999) Worksafe Australia (1996), Hazardous Substance, Toluene-2,4-diisocyanate (February 1999) … endobj Autres études. (April 1996). * Many scientists believe there is no safe level of exposure to a carcinogen. When rats and mice were exposed orally to commercial-grade TDI (an 80:20 mixture of 2,4- and 2,6-TDI), tumors were induced in both species. Reaction with water to form Carbon Dioxide [Merck 11th ed. According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). Les isocyanates, notamment le toluène de diisocyanate (TDI), et l'hexaméthylène di-isocyanate (HDI) constituent la première cause d’asthme chimique professionnel. Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. Gives off irritating or toxic fumes (or gases) in a fire. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview .

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